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GHC Genetics to use innovative approach in sequencing oral and intestinal microbiome

Nanopore sequencing belongs to the so-called "third generation" of sequencing, which allows direct reading of single-stranded DNA or RNA without the need for prior amplification (e.g., using PCR) or chemical labeling. The use of nanopores for sequencing was first described in the late 1980s by several American scientists. David Deamer, George Church, and Hagan Bayley independently described the sequencing of a single DNA molecule using electrophoresis and membrane nanopores. This method does not use a fluorescent signal, but measures the voltage changes that occur when DNA passes through an electrically charged pore in the membrane.